pratyakṣam aitihyam athānumānam
ādy-antayor asya yad eva kevalaṁ
kālaś ca hetuś ca tad eva madhye
Material scientists and philosophers are desperately searching for the ultimate material cause or principle, which is described here as kāla, the time factor. The material process of cause and effect takes place entirely within a sequence of time; in other words, the time factor is the motivating impetus for material cause and effect. This time factor is a manifestation of the Supersoul, the form of the Supreme Lord that pervades and supports the cosmic manifestation. The method for acquiring knowledge is scientifically described here, and those who are serious, reasonable scholars will take advantage of the transcendental epistemology revealed here by the Lord.