SB 10.74.53

duryodhanam ṛte pāpaṁ
 kaliṁ kuru-kulāmayam
yo na sehe śrīyaṁ sphītāṁ
 dṛṣṭvā pāṇḍu-sutasya tām
Synonyms: 
duryodhanam — Duryodhana; ṛte — except; pāpam — sinful; kalim — the empowered expansion of the personality of Kali; kuru-kula — of the Kuru dynasty; āmayam — the disease; yaḥ — who; na sehe — could not tolerate; śrīyam — the opulences; sphītām — flourishing; dṛṣṭvā — seeing; pāṇḍu-sutasya — of the son of Pāṇḍu; tām — that.
Translation: 
[All were satisfied] except sinful Duryodhana, the personification of the age of quarrel and the disease of the Kuru dynasty. He could not bear to see the flourishing opulence of the son of Pāṇḍu.
Purport: 

Śrīla Prabhupāda writes: “Duryodhana by nature was very envious because of his sinful life, and he appeared in the dynasty of the Kurus as a chronic disease personified in order to destroy the whole family.” Śrīla Śrīdhara Svāmī mentions that Duryodhana hated pure religious principles.